Publications of studies that have used Ontario Tumour Bank samples and data:
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Applying Serum Cytokine Levels to Predict Pain Severity in Cancer PatientsJ Pain Res. 2020;13:313-321. https://doi.org/10.2147/JPR.S227175
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Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSigNature Communications volume 11, Article number: 731 (2020). https://doi.org/10.1038/s41467-020-14352-7
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Divergent mutational processes distinguish hypoxic and normoxic tumoursNature Communications volume 11, Article number: 737 (2020) . https://doi.org/10.1038/s41467-019-14052-x
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Inferring structural variant cancer cell fractionNature Communications volume 11, Article number: 730 (2020) . https://doi.org/10.1038/s41467-020-14351-8
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Combined burden and functional impact tests for cancer driver discovery using DriverPowerNature Communications volume 11, Article number: 734 (2020). https://doi.org/10.1038/s41467-019-13929-1
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Genomic footprints of activated telomere maintenance mechanisms in cancerNature Communications volume 11, Article number: 733 (2020). https://doi.org/10.1038/s41467-019-13824-9
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High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterationsNature Communications volume 11, Article number: 736 (2020) . https://doi.org/10.1038/s41467-019-13885-w
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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patternsNature Communications volume 11, Article number: 728 (2020). https://doi.org/10.1038/s41467-019-13825-8
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Pathway and network analysis of more than 2500 whole cancer genomes
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Integrative pathway enrichment analysis of multivariate omics dataNature Communications volume 11, Article number: 735 (2020). https://doi.org/10.1038/s41467-019-13983-9
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Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesisCommunications Biology volume 3, Article number: 56 (2020). https://doi.org/10.1038/s42003-019-0741-7
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Butler enables rapid cloud-based analysis of thousands of human genomesNature Biotechnology volume 38, pages288–292(2020). https://doi.org/10.1038/s41587-019-0360-3
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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencingNature Genetics volume 52, pages331–341(2020). https://doi.org/10.1038/s41588-019-0576-7
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The landscape of viral associations in human cancersNature Genetics volume 52, pages320–330(2020). https://doi.org/10.1038/s41588-019-0558-9
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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotranspositionNature Genetics volume 52, pages306–319(2020). https://doi.org/10.1038/s41588-019-0562-0
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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancerNature Genetics volume 52, pages294–305(2020). https://doi.org/10.1038/s41588-019-0564-y
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Comprehensive molecular characterization of mitochondrial genomes in human cancersNature Genetics volume 52, pages342–352(2020). https://doi.org/10.1038/s41588-019-0557-x
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Analyses of non-coding somatic drivers in 2,658 cancer whole genomesNature volume 578, pages102–111(2020). https://doi.org/10.1038/s41586-020-1965-x
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Genomic basis for RNA alterations in cancerNature volume 578, pages129–136(2020). https://doi.org/10.1038/s41586-020-1970-0
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The evolutionary history of 2,658 cancersNature volume 578, pages122–128(2020). https://doi.org/10.1038/s41586-019-1907-7
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The repertoire of mutational signatures in human cancerNature volume 578, pages94–101(2020). https://doi.org/10.1038/s41586-020-1943-3
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Patterns of somatic structural variation in human cancer genomesNature volume 578, pages112–121(2020). https://doi.org/10.1038/s41586-019-1913-9
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Pan-cancer analysis of whole genomesNature volume 578, pages82–93(2020). https://doi.org/10.1038/s41586-020-1969-6
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The entry of nanoparticles into solid tumoursNature Materials volume 19, pages566–575(2020). https://doi.org/10.1038/s41563-019-0566-2
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Region-specific glucocorticoid receptor promoter methylation has both positive and negative prognostic value in patients with estrogen receptor-positive breast cancerClinical Epigenetics volume 11, Article number: 155 (2019). https://doi.org/10.1186/s13148-019-0750-x
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Coding and non-coding drivers of mantle cell lymphoma identified through exome and genome sequencingblood, March 2020. https://doi.org/10.1182/blood.2019002385
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Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cellsBMC Cancer volume 19, Article number: 561 (2019). https://doi.org/10.1186/s12885-019-5771-5
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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectivesFrontiers of Medicine,13, pages 438–450 (2019). https://doi.org/10.1007/s11684-018-0674-4
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The role of circulating extracellular vesicles in breast cancer classification and molecular subtypingThe Breast Journal, September 2018. https://doi.org/10.1111/tbj.13309
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Comparison of two X-ray detection systems used to investigate properties ofnormal and malignant breast tissuesNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. February 2019, https://doi.org/10.1016/j.nima.2019.02.027
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Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast CancerCancers 2019, 11(7), 938; https://doi.org/10.3390/cancers11070938
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Canadian Tumour Repository NetworkBiopreservation and Biobanking. December 2010, 8(4): 181-185. https://doi.org/10.1089/bio.2010.8405
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RNA and DNA Integrity Remain Stable in Frozen Tissue After Long-Term Storage at Cryogenic Temperatures: A Report from the Ontario Tumour BankBiopreservation and Biobanking 2019. DOI:https://doi.org/10.1089/bio.2018.0095
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Perspective on Oncogenic Processes at the End of the Beginning of Cancer GenomicsCell 2018. 173, 305–320, DOI:https://doi.org/10.1016/j.cell.2018.03.033
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A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient SamplesCell 2018. 173, 386–399, DOI:https://doi.org/10.1016/j.cell.2018.03.027
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The Plasma Peptides of Ovarian CancerClin Proteom 2018. 15:41, DOI:https://doi.org/10.1186/s12014-018-9215-z
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Integrative Molecular Characterization of Malignant Pleural MesotheliomaCANCER DISCOVERY 2018. CD-18-0804, DOI: 10.1158/2159-8290
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Comprehensive Molecular Characterization of the Hippo Signaling Pathway in CancerCell Reports 2018. 25, 1304–1317 , DOI:https://doi.org/10.1016/j.celrep.2018.10.001
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The chromatin accessibility landscape of primary human cancersScience 26 Oct 2018: Vol. 362, Issue 6413, eaav1898 DOI: 10.1126/science.aav1898
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A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β SuperfamilyCell Systems 2018. 7, 422–437, DOI:https://doi.org/10.1016/j.cels.2018.08.010
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Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 PatientsCancer Cell 2018. 34, 211–224, DOI:https://doi.org/10.1016/j.ccell.2018.07.001
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Integrated Molecular Characterization of Testicular Germ Cell TumorsCell Reports 2018. 23, 3392–3406, DOI:https://doi.org/10.1016/j.celrep.2018.05.039
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Infantile Pulmonary Teratoid TumorN Engl J Med. 2018 Jun 7;378(23):2238-2240. doi: 10.1056/NEJMc1803354
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The Immune Landscape of CancerImmunity 2018. 48, 812–830, DOI:https://doi.org/10.1016/j.immuni.2018.03.023
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lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in CancerCancer Cell 2018. 33, 706–720, DOI:https://doi.org/10.1016/j.ccell.2018.03.006
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A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast CancersCancer Cell 2018. 33, 690–705, DOI:https://doi.org/10.1016/j.ccell.2018.03.014
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Comparative Molecular Analysis of Gastrointestinal AdenocarcinomasCancer Cell 2018. 33, 721–735, DOI: https://doi.org/10.1016/j.ccell.2018.03.010
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Genomic and Functional Approaches to Understanding Cancer AneuploidyCancer Cell 2018. 33, 676–689, DOI:https://doi.org/10.1016/j.ccell.2018.03.007
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Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of CancerCell 2018. 173, 291–304, DOI:https://doi.org/10.1016/j.cell.2018.03.022
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SnapShot: TCGA-Analyzed TumorsCell 2018. 173(2):530. doi: 10.1016/j.cell.2018.03.059.
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Oncogenic Signaling Pathways in The Cancer Genome AtlasCell 2018. 173, 321–337, DOI:https://doi.org/10.1016/j.cell.2018.03.035
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An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome AnalyticsCell 2018. 173, 400–416, doi:https://doi.org/10.1016/j.cell.2018.02.052
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Comprehensive Characterization of Cancer Driver Genes and MutationsCell 2018. 173, 371–385, doi: https://doi.org/10.1016/j.cell.2018.02.060
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Machine Learning Identifies Stemness Features Associated with Oncogenic DedifferentiationCell 2018. 173, 338–354, doi: https://doi.org/10.1016/j.cell.2018.03.034
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Pathogenic Germline Variants in 10,389 Adult CancersCell 2018. 173, 355–370, doi:https://doi.org/10.1016/j.cell.2018.03.039
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Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer TypesCell Reports 2018. 23, 213–226, doi: https://doi.org/10.1016/j.celrep.2018.03.047
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Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous CarcinomasCell Reports 2018. 23, 194–212, doi: https://doi.org/10.1016/j.celrep.2018.03.063
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Driver Fusions and Their Implications in the Development and Treatment of Human CancersCell Reports 2018. 23, 227–238, doi: https://doi.org/10.1016/j.celrep.2018.03.050
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Genomic and Molecular Landscape of DNA Damage Repair Deficiency Across The Cancer Genome AtlasCell Reports 2018. 23, 239–254, doi: https://doi.org/10.1016/j.celrep.2018.03.076
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Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome AtlasCell Reports 2018. 23, 172–180, doi: https://doi.org/10.1016/j.celrep.2018.03.046
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Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology ImagesCell Reports 2018. 23, 181–200, doi: https://doi.org/10.1016/j.celrep.2018.03.086
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Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor ContextCell Reports 2018. 23, 297–312, doi: https://doi.org/10.1016/j.celrep.2018.03.064
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Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer TypesCell Reports 2018. 23, 282–296, doi: https://doi.org/10.1016/j.celrep.2018.01.088
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Systematic Analysis of Splice-Site-Creating Mutations in CancerCell Reports 2018. 23, 270–281, doi: https://doi.org/10.1016/j.celrep.2018.03.052
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Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human CancersCell Reports 2018. 23, 255–273, doi: https://doi.org/10.1016/j.celrep.2018.03.077
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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell CarcinomaCell Reports 2018. 23, 313–326, doi: https://doi.org/10.1016/j.celrep.2018.03.075
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Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic PipelinesCell Systems 2018. 6, 271–281. doi: https://doi.org/10.1016/j.cels.2018.03.002
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Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome AtlasCell Systems 2018. 6, 282–300. doi: https://doi.org/10.1016/j.cels.2018.03.003
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Characteristics and Outcome of the COEUR, Canadian Validation Cohort for Ovarian Cancer BiomarkersBMC Cancer 2018. 18:347, doi: https://doi.org/10.1186/s12885-018-4242-8
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Disrupting the Interaction Between Anti-GRP78 Autoantibodies and Cell Surface GRP78 With Low Molecular Weight Heparin as a Treatment for Prostate CancerEuropean Urology Supplements 2018. Volume 17, Issue 2, Page e509. doi: https://doi.org/10.1016/S1569-9056(18)31200-4
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Cell Surface GRP78 Activation by Anti-GRP78 Autoantibodies in Relation to Prostate Tumour Growth via Tissue Factor ActivationJournal of Clinical Oncology 36, no. 6_suppl (February 20 2018) 31-31. DOI: 10.1200/JCO.2018.36.6_suppl.31
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The Integrated Genomic Landscape of Thymic Epithelial TumorsCancer Cell 2018. 33, 244–258 doi:https://doi.org/10.1016/j.ccell.2018.01.003
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Genome Analysis and Data Sharing Informs Timing of Molecular Events in Pancreatic Neuroendocrine TumourbioRxiv 2018. doi:http://dx.doi.org/10.1101/232850
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COX-2 Induces Oncogenic Micro RNA miR655 in Human Breast CancerSci Rep. 2018 Jan 10;8(1):327. doi: 10.1038/s41598-017-18612-3.
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A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA ‘grey zone’World J Urol (2018) 36: 341. https://doi.org/10.1007/s00345-017-2152-z
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Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue SarcomasCell. 2017 November 02; 171(4): 950–965.e28. doi:10.1016/j.cell.2017.10.014.
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Comprehensive Molecular Characterization of Muscle-Invasive Bladder CancerCell 2017. 171, 540–556 DOI: https://doi.org/10.1016/j.cell.2017.09.007
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53BP1 is a Novel Independent Predictive Biomarker in High-grade Serous Ovarian CancerPoster
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Clinical Characteristics and Outcome of the COEUR Cohort, a Canadian Repository for Ovarian Cancer Biomarker ValidationPoster 2017
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Validation of Biomarkers in Epithelial Ovarian CancerPoster
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Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factorJ. Biol. Chem.(2017) 292(51) 21180–21192 DOI: http://www.jbc.org/cgi/doi/10.1074/jbc.M117.799908
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Integrated Genomic Characterization of Pancreatic Ductal AdenocarcinomaCancer Cell 2017. 32:185–203, DOI: http://dx.doi.org/10.1016/j.ccell.2017.07.007
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The 2017 ISBER Annual Meeting & Exhibits: “Due North: Aligning Biobanking Practice with Evolving Evidence and Innovation”Biopreservation and Biobanking 2017, 15(3), pp. 280–281 DOI: https://doi.org/10.1089/bio.2017.29024.apj
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Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma Via c-myc-dependent and independent eventsScientific Reports 7:42342 (2017) DOI: 10.1038/srep42342
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Integrated Genomic and Molecular Characterization of Cervical CancerNature volume 543, pages 378–384, 23 January 2017, doi:10.1038/nature21386
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The 2017 ISBER Annual Meeting & Exhibits in Toronto “Due North: Aligning Biobanking Practice with Evolving Evidence and InnovationBiopreservation and Biobanking 2016 Dec;14(6):563-564. Epub 2016 Nov 21 https://doi.org/10.1089/bio.2016.29013.apj
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STAT1-associated intratumoural TH1 immunity predicts chemotherapy resistance in high-grade serous ovarian cancerJ Path: Clin Res October 2016; 2: 259–270 DOI: 10.1002/cjp2.55
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COEUR: A pan Canadian platform for the development of biomarker-driven subtype specific management of ovarian cancerPoster 2016
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Effect of anti-GRP78 autoantibodies on prostate cancer progression through tissue factor procoagulant activityJournal of Clinical Oncology 34, no. 2_suppl (January 2016) 258-258. DOI: 10.1200/jco.2016.34.2_suppl.258
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COEUR: A pan Canadian platform for the development of biomarker-driven subtype specific management of ovarian cancerPoster
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Finding the Path to Biobank Sustainability Through Sound Business PlanningBiopreservation and Biobanking 2015 Dec;13(6):385-6 https://doi.org/10.1089/bio.2015.29039.mh
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Funding Sources for Canadian Biorepositories: The Role of User Fees and Strategies to Help Fill the GapBiopreservation and Biobanking. October 2014, 12(5): 300-305. https://doi.org/10.1089/bio.2014.0052
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Frequent Promoter Hypermethylation and Expression Reduction of the Glucocorticoid Receptor Gene in Breast TumoursEpigenetics, 9:6, 851-859, DOI: 10.4161/epi.28484
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A Framework for Biobank SustainabilityBiopreservation and Biobanking. February 2014, 12(1): 60-68; https://doi.org/10.1089/bio.2013.0064
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Certification for Biobanks: The Program Developed by the Canadian Tumour Repository Network (CTRNet)Biopreserv Biobank. 2012 Oct;10(5):426-32. doi: 10.1089/bio.2012.0026.
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Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesionOncogene. 2017; doi:10.1038/onc.2017.372
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DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxiaProc Natl Acad Sci USA. 2014; 111(21): 7783–7788.
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An Immunohistochemical Algorithm for Ovarian Carcinoma TypingInternational Journal of Gynecological Pathology. 2016; 35:430–441. DOI: 10.1097/PGP.0000000000000274
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Integrated genomic characterization of oesophageal carcinomaNature. 2017; doi:10.1038/nature20805.
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RBM5 reduces small cell lung cancer growth, increases cisplatin sensitivity and regulates key transformation-associated pathwaysHeliyon 2016 2(11): e00204, DOI: 10.1016/j.heliyon.2016.e00204
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COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis.Stem Cells. 2016; 14. doi: 10.1002/stem.2426.
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Hexokinase II expression is correlated with colorectal cancer prognosis.Cancer Treatment and Research Communications. 2016; 6: 11-16. DOI: https://doi.org/10.1016/j.ctrc.2016.02.008
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Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.N Engl J Med. 2016; 14:135-45. doi: 10.1056/NEJMoa1505917.
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Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer.Applied Mathematics, Medicine, Cell Biology, 2016; 2(1): DOI: 10.1016/j.heliyon.2015.e00059.
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COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation.Mol Cancer Res. 2015; 13:1022-33. doi: 10.1158/1541-7786.MCR-14-0543.
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A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer.Br J Cancer. 2015; 113:1746. doi:10.1038/bjc.2015.459.
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Biobank bootstrapping: is biobank sustainability possible through cost recovery?
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Investigating Ochratoxin A and Biotin Levels in Patients with Renal Carcinoma.Northeastern Section of the American Urological Association 64th Annual Meeting, Niagara Falls, Canada. September 2012. Moderated Poster
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Endogenous biotin expression in renal and testicular tumours and literature review.Canadian Urological Association Journal. 2014; 8: 268- 272.doi:10.5489/cuaj.1810.
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A practical tool for modeling biospecimen user fees.Biopreserv Biobank. 2014;12: 234-9. doi: 10.1089/bio.2014.0008.
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Comprehensive molecular characterization of gastric adenocarcinoma.Nature. 2014; 11: 202-9. doi: 10.1038/nature13480.
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Comprehensive molecular profiling of lung adenocarcinoma.Nature. 2014; 511:543-50. doi: 10.1038/nature13385.
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Comprehensive molecular characterization of urothelial bladder carcinoma.Nature. 2014; 507: 315-22. doi: 10.1038/nature12965.
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Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.British Journal of Cancer. 2014; 111: 726-735.
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Ochratoxin A is not detectable in renal and testicular tumours.Canadian Urological Association Journal. 2014; 8: 40-6.
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Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.Int. J. Cancer: 2014; 134: 2330–2341.
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Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines.International Journal of Oncology, 2013; 43: Issue 2.
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Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.The Pharmacogenomics Journal. 2013; 13: 148–158.
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Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas.Acta Neuropathol. 2013; 125:659–669.
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Pharmacologic inhibition of MEK signaling prevents growth of canine hemangiosarcoma.Molecular Cancer Theraputics, 2013; 12: 1701-1714.
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Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.Nature Genetics 2013; 45: 478-486.
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Cholesterol masks membrane glycosphingolipid tumor-associated antigens to reduce their immunodectection in human cancer biopsies.Glycobiology. 2013; 23.1230-9.
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Identification of the IGF1/PI3K/NF κB/ERK gene signaling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer.BMC Cancer. 2013; 13: 549.
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The use of X-ray interaction data to differentiate malignant from normal breast tissue at surgical margins and biopsy analysis.X-Ray Spectrom. 2013; 42, 349–358.
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Integrated genomic characterization of endometrial carcinoma.Nature. 2013: 497, 67-73. doi: 10.1038/nature12113.
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Generating a comprehensive set of standard operating procedures for a biorepository network-The CTRNet experience.Biopreserv Biobank. 2013; 11:387-96. doi: 10.1089/bio.2013.0061.
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Application of Selected Reaction Monitoring for Multiplex Quantification of Clinically Validated Biomarkers in Formalin-Fixed, Paraffin-Embedded Tumour Tissue.The Journal of Molecular Diagnostics. 2013; 15: 454-465.
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Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer.Int. J. Cancer. 2012; 130: 1844–1854. doi:10.1002/ijc.26189.
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EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer.BMC Cancer. 2012;12:91. doi:10.1186/1471-2407-12-91.
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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.Nature. 2012;482:226–231.
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Intra-protein variability revealed by absolute quantification of plasma proteins using dimethyl labelling.Paper presented at: 4th Annual Symposium of the Canadian National Proteomics Network; 2012 Apr 23-25; Toronto, ON.
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Investigating Ochratoxin A and Biotin Levels in Patients with Renal Carincoma.Paper presented at: 64th Annual Meeting of the Northeastern Section of the American Urological Association; 2012 Sep 13-15; Niagara Falls.
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Comprehensive genomic characterization of squamous cell lung cancers.Nature.2012; 489(7417), 519–525. http://doi.org/10.1038/nature11404
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Embryonic protein nodal promotes breast cancer vascularization.Cancer Research. 72; 3851–63.
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Proteomic Profiling of a Mouse Model for Ovarian Granulosa Cell Tumor Identifies VCP as a Highly Sensitive Serum Tumor Marker in Several Human Cancers.PLoS ONE. 2012; 7(8): e42470. doi:10.1371/journal.pone.0042470.
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Pharmacological targeting of mammalian target of rapamycin inhibits ovarian granulosa cell tumor growth.Carcinogenesis. 2012;33(11):2283–92. doi: 10.1093/carcin/bgs263.
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New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer.Life Sciences. 2012; 91(21-22), 1103–1108. http://doi.org/10.1016/j.lfs.2011.12.023.
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The differentiation of malignant and benign human breast tissue at surgical margins and biopsy using x-ray interaction data and Bayesian classification.Radiation of Physics and Chemistry.2012; 95: 210-2013. http://dx.doi.org/10.1016/j.radphyschem.2012.12.014.
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Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma.Cancer Research. 2012;72(20):5273–5284. doi: 10.1158/0008-5472.CAN-12-0656.
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Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses.PLoS ONE. 2011; 6(12), e28683. http://doi.org/10.1371/journal.pone.0028683.
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Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice.BMC cancer. 2011; 71. doi:101186/1471-2407-11-71.
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NT-proBNP measurement using a multiplex platform in cancer and chest pain populations.Clinical Biochemistry. 2011; 44: 1172.
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Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma.Acta Neuropathol. 2011; 121: 763. doi:10.1007/s00401-011-0817-z.
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Histone methylation is a critical regulator of the abnormal expression of POU5F1 and RASSF1A in testis cancer cell lines.International Journal of Andrology. 2011; 34: 110–123. doi:10.1111/j.1365-2605.2010.01063.x
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Identification of vascular breast tumour markers by laser capture microdissection and label-free LC-MS.J Proteome Res. 2011; 10(5): 2479-2493.
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miRNA Profiling in Metastatic Renal Cell Carcinoma Reveals a Tumour-Suppressor Effect for miR-215.British Journal of Cancer. 2011; 105(11): 1741–1749.
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Establishing a reference interval for the high sensitive Troponin T assay in treatment-naïve cancer patients.Accepted abstract in: AACC; 2011.
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Identification of a Novel HSP70-binding Cochaperone Critical to HSP90-mediated Activation of Small Serine/Threonine Kinase.The Journal of Biological Chemistry. 2010; 285(45):35180-35187. doi:10.1074/jbc.M110.134767.
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Analyzing The Biological Role Of The Transcription Factor Kaiso In Breast Tumourigenesis.Graduate Studies. McMaster University, 2010. Print.
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Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer.Molecular and Cellular Biology. 2011; 31(1):138-150. doi:10.1128/MCB.00709-10.
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A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions.Cancer Cell International. 2010; 10:8. doi:10.1186/1475-2867-10-8.
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Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma.Acta Neuropathol. 2010; 121: 229. doi:10.1007/s00401-010-0780-0.
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Kaiso regulates Znf131-mediated transcriptional activation.Exp Cell Res. 2010; 316: 1692–1705.
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An algorithm for classifying tumors based on genomic aberrations and selecting representative tumor models.BMC Med Genomics. 2010; 3: 23.
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Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer.Heliyon. 2010; 2(1):e00059. doi:10.1016/j.heliyon.2015.e00059.
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Amplification of mRNA from Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues without 3' Bias and Multiplex Expression Analysis on Flow-Through Microarrays.Cancer Res. 2009; 69: 3052; DOI: 10.1158/0008-5472.SABCS-09-3052.
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Cytokine elevations in acute coronary syndrome and ovarian cancer: a mechanism for the up-regulation of the acute phase proteins in these different disease etiologies.Clin Biochem. 2008; 41:607–610.
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Pilot study assessing the utility of an adhesion array and high-sensitivity cytokine array as surrogate biomarkers in ovarian cancer.Clin Biochem. 2008; 41:1271.