Publications of studies that have used Ontario Tumour Bank samples and data:

  1. Hunter, S.; Nault, B.; Ugwuagbo, K.C.; Maiti, S.; Majumder, M.
    Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast Cancer
    Cancers 2019, 11(7), 938; https://doi.org/10.3390/cancers11070938
  2. .
    Canadian Tumour Repository Network
    Biopreservation and Biobanking. December 2010, 8(4): 181-185. https://doi.org/10.1089/bio.2010.8405
  3. Kelly R, Albert M, de Ladurantaye M, Moore M, Dokun O, Bartlett J
    RNA and DNA Integrity Remain Stable in Frozen Tissue After Long-Term Storage at Cryogenic Temperatures: A Report from the Ontario Tumour Bank
    Biopreservation and Biobanking 2019. DOI:https://doi.org/10.1089/bio.2018.0095
  4. Ding L, Bailey MH, Porta-Pardo E,
    Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
    Cell 2018. 173, 305–320, DOI:https://doi.org/10.1016/j.cell.2018.03.033
  5. Chen H, Li C, Peng X, Zhou Z, Weinstein JN, The Cancer Genome Atlas Research Network, Liang H
    A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples
    Cell 2018. 173, 386–399, DOI:https://doi.org/10.1016/j.cell.2018.03.027
  6. Dufresne J, Bowden P, Thavarajah T, Florentinus‑Mefailoski A, et al
    The Plasma Peptides of Ovarian Cancer
    Clin Proteom 2018. 15:41, DOI:https://doi.org/10.1186/s12014-018-9215-z
  7. Hmeljak J, Sanchez-Vega F, Hoadley KA, Shih J, et al
    Integrative Molecular Characterization of Malignant Pleural Mesothelioma
    CANCER DISCOVERY 2018. CD-18-0804, DOI: 10.1158/2159-8290
  8. Wang Y, Xu X, Maglic D, et al
    Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
    Cell Reports 2018. 25, 1304–1317 , DOI:https://doi.org/10.1016/j.celrep.2018.10.001
  9. Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, et al
    The chromatin accessibility landscape of primary human cancers
    Science 26 Oct 2018: Vol. 362, Issue 6413, eaav1898 DOI: 10.1126/science.aav1898
  10. Korkut A, Zaidi S, Kanchi RS, et al
    A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
    Cell Systems 2018. 7, 422–437, DOI:https://doi.org/10.1016/j.cels.2018.08.010
  11. Kahles A, Lehmann K, Toussaint NC, et al
    Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients
    Cancer Cell 2018. 34, 211–224, DOI:https://doi.org/10.1016/j.ccell.2018.07.001
  12. Shen H, Shih J, Hollern DP, et al
    Integrated Molecular Characterization of Testicular Germ Cell Tumors
    Cell Reports 2018. 23, 3392–3406, DOI:https://doi.org/10.1016/j.celrep.2018.05.039
  13. de Kock L, Fahiminiya S, Fiset PO, Astigarraga I, Nguyen VH, Albrecht S, Foulkes WD.
    Infantile Pulmonary Teratoid Tumor
    N Engl J Med. 2018 Jun 7;378(23):2238-2240. doi: 10.1056/NEJMc1803354
  14. Thorsson V, Gibbs DL, Brown SD, et al
    The Immune Landscape of Cancer
    Immunity 2018. 48, 812–830, DOI:https://doi.org/10.1016/j.immuni.2018.03.023
  15. Wang Z, Yang B, Zhang M, et al
    lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer
    Cancer Cell 2018. 33, 706–720, DOI:https://doi.org/10.1016/j.ccell.2018.03.006
  16. Berger AC, Korkut A, Kanchi RS, et al
    A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
    Cancer Cell 2018. 33, 690–705, DOI:https://doi.org/10.1016/j.ccell.2018.03.014
  17. Liu Y, Sethi NS,Hinoue T, et al
    Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas
    Cancer Cell 2018. 33, 721–735, DOI: https://doi.org/10.1016/j.ccell.2018.03.010
  18. Taylor AM, Shih J, Ha G
    Genomic and Functional Approaches to Understanding Cancer Aneuploidy
    Cancer Cell 2018. 33, 676–689, DOI:https://doi.org/10.1016/j.ccell.2018.03.007
  19. Hoadley KA, Yau C, Hinoue T
    Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer
    Cell 2018. 173, 291–304, DOI:https://doi.org/10.1016/j.cell.2018.03.022
  20. Blum A, Wang P, Zenklusen JC
    SnapShot: TCGA-Analyzed Tumors
    Cell 2018. 173(2):530. doi: 10.1016/j.cell.2018.03.059.
  21. Sanchez-Vega F, Mina M, Armenia J, et al
    Oncogenic Signaling Pathways in The Cancer Genome Atlas
    Cell 2018. 173, 321–337, DOI:https://doi.org/10.1016/j.cell.2018.03.035
  22. Liu J, Lichtenberg T, Hoadley KA, et al
    An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
    Cell 2018. 173, 400–416, doi:https://doi.org/10.1016/j.cell.2018.02.052
  23. Bailey MH, Tokheim C, Porta-Pardo E et al
    Comprehensive Characterization of Cancer Driver Genes and Mutations
    Cell 2018. 173, 371–385, doi: https://doi.org/10.1016/j.cell.2018.02.060
  24. Malta TM, Sokolov A, Andrew J. Gentles, et al
    Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
    Cell 2018. 173, 338–354, doi: https://doi.org/10.1016/j.cell.2018.03.034
  25. Huang K, Mashl RJ, Wu Y et al
    Pathogenic Germline Variants in 10,389 Adult Cancers
    Cell 2018. 173, 355–370, doi:https://doi.org/10.1016/j.cell.2018.03.039
  26. Ge Z, Leighton JS, Wang Y, et al
    Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types
    Cell Reports 2018. 23, 213–226, doi: https://doi.org/10.1016/j.celrep.2018.03.047
  27. Campbell JD, Yau C, Bowlby R, et al
    Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
    Cell Reports 2018. 23, 194–212, doi: https://doi.org/10.1016/j.celrep.2018.03.063
  28. Gao Q, Liang W, Foltz SM, et al
    Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
    Cell Reports 2018. 23, 227–238, doi: https://doi.org/10.1016/j.celrep.2018.03.050
  29. Knijnenburg TA
    Wang L, Zimmermann MT, Chambwe N, et al
    Genomic and Molecular Landscape of DNA Damage Repair Deficiency Across The Cancer Genome Atlas
    Cell Reports 2018. 23, 239–254, doi: https://doi.org/10.1016/j.celrep.2018.03.076
  30. Way GP
    Sanchez-Vega F, La K, Armenia J, et al
    Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas
    Cell Reports 2018. 23, 172–180, doi: https://doi.org/10.1016/j.celrep.2018.03.046
  31. Saltz J
    Gupta R, Hou L, Kurc T, Singh P, Nguyen V, et al
    Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
    Cell Reports 2018. 23, 181–200, doi: https://doi.org/10.1016/j.celrep.2018.03.086
  32. Chiu H
    Somvanshi S, Patel E, Chen T, Singh VP, et al
    Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
    Cell Reports 2018. 23, 297–312, doi: https://doi.org/10.1016/j.celrep.2018.03.064
  33. Seiler M
    Peng A, Agrawal AA, Palacino J
    et al
    Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types
    Cell Reports 2018. 23, 282–296, doi: https://doi.org/10.1016/j.celrep.2018.01.088
  34. Jayasinghe RG
    Cao S, Gao Q, Wendl MC
    et al
    Systematic Analysis of Splice-Site-Creating Mutations in Cancer
    Cell Reports 2018. 23, 270–281, doi: https://doi.org/10.1016/j.celrep.2018.03.052
  35. Peng X
    Chen Z, Farshidfar F, Xu X
    et al
    Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers
    Cell Reports 2018. 23, 255–273, doi: https://doi.org/10.1016/j.celrep.2018.03.077
  36. Ricketts C
    De Cubas AA, Fan H, Smith CC, Lang M
    et al
    The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
    Cell Reports 2018. 23, 313–326, doi: https://doi.org/10.1016/j.celrep.2018.03.075
  37. Ellrott K
    Bailey MH, Saksena G, Covington KR, Kandoth C
    et al
    Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines
    Cell Systems 2018. 6, 271–281. doi: https://doi.org/10.1016/j.cels.2018.03.002
  38. Schuab FX
    Dhankani V, Berger AC
    et al
    Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
    Cell Systems 2018. 6, 282–300. doi: https://doi.org/10.1016/j.cels.2018.03.003
  39. Le Page C
    Rahimi K, Köbel M, Tonin PN, Meunier L
    et al
    Characteristics and Outcome of the COEUR, Canadian Validation Cohort for Ovarian Cancer Biomarkers
    BMC Cancer 2018. 18:347, doi: https://doi.org/10.1186/s12885-018-4242-8
  40. Al-Hashimi A
    Hoogenes J, Lebeau P, Shayegan B, Austin R
    Disrupting the Interaction Between Anti-GRP78 Autoantibodies and Cell Surface GRP78 With Low Molecular Weight Heparin as a Treatment for Prostate Cancer
    European Urology Supplements 2018. Volume 17, Issue 2, Page e509. doi: https://doi.org/10.1016/S1569-9056(18)31200-4
  41. Al-Hashimi A , Austin R, Shayegan B
    Cell Surface GRP78 Activation by Anti-GRP78 Autoantibodies in Relation to Prostate Tumour Growth via Tissue Factor Activation
    Journal of Clinical Oncology 36, no. 6_suppl (February 20 2018) 31-31. DOI: 10.1200/JCO.2018.36.6_suppl.31
  42. Radovich M
    Pickering CR, Felau I, Ha G, Zhang H
    et al
    The Integrated Genomic Landscape of Thymic Epithelial Tumors
    Cancer Cell 2018. 33, 244–258 doi:https://doi.org/10.1016/j.ccell.2018.01.003
  43. Quevedo R
    Spreafico A, Bruce J, Danesh A, Giesler A
    et al
    Genome Analysis and Data Sharing Informs Timing of Molecular Events in Pancreatic Neuroendocrine Tumour
    bioRxiv 2018. doi:http://dx.doi.org/10.1101/232850
  44. Majumder M
    Dunn L, Liu L, Hasan A, Vincent K, Brackstone M, Hess D, Lala PK
    COX-2 Induces Oncogenic Micro RNA miR655 in Human Breast Cancer
    Sci Rep. 2018 Jan 10;8(1):327. doi: 10.1038/s41598-017-18612-3.
  45. Creed, J., Klotz, L., Harbottle, A. et al
    A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA ‘grey zone’
    World J Urol (2018) 36: 341. https://doi.org/10.1007/s00345-017-2152-z
  46. The Cancer Genome Atlas Group
    Bartlett J, Sekhon H, Parfitt J
    Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
    Cell. 2017 November 02; 171(4): 950–965.e28. doi:10.1016/j.cell.2017.10.014.
  47. The Cancer Genome Atlas Group
    Albert M, Alexopoulou V, Bartlett J, Paraffit J
    Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
    Cell 2017. 171, 540–556 DOI: https://doi.org/10.1016/j.cell.2017.09.007
  48. Skulimowski
    et al
    53BP1 is a Novel Independent Predictive Biomarker in High-grade Serous Ovarian Cancer
    Poster
  49. Le Page C
    Kobel M, Rahimi K, Bernardini M, Meunier L, Porlelance L, de Ladurantaye M
    Clinical Characteristics and Outcome of the COEUR Cohort, a Canadian Repository for Ovarian Cancer Biomarker Validation
    Poster 2017
  50. Communal et al
    Validation of Biomarkers in Epithelial Ovarian Cancer
    Poster
  51. Al-Hashimi AA
    Lebeau P, Majeed F, Polena E, Lhotak Š, Collins CAF, Pinthus JH
    et al
    Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor
    J. Biol. Chem.(2017) 292(51) 21180–21192 DOI: http://www.jbc.org/cgi/doi/10.1074/jbc.M117.799908
  52. The Cancer Genome Atlas Group
    Bartlett J, Albert M, Sekhon H
    Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
    Cancer Cell 2017. 32:185–203, DOI: http://dx.doi.org/10.1016/j.ccell.2017.07.007
  53. Parry-Jones A
    Albert M
    The 2017 ISBER Annual Meeting & Exhibits: “Due North: Aligning Biobanking Practice with Evolving Evidence and Innovation”
    Biopreservation and Biobanking 2017, 15(3), pp. 280–281 DOI: https://doi.org/10.1089/bio.2017.29024.apj
  54. Crawford TE
    Marcellus KA, Langill J, Ravel-Chapuis A, Michaud J, Cowan KN, Cote J, Jasmin BJ
    Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma Via c-myc-dependent and independent events
    Scientific Reports 7:42342 (2017) DOI: 10.1038/srep42342
  55. The Cancer Genome Atlas Group
    Albert M, Bartlett J, Parfitt J, Arnaout A, Sekhon H, Gilbert S
    Integrated Genomic and Molecular Characterization of Cervical Cancer
    Nature volume 543, pages 378–384, 23 January 2017, doi:10.1038/nature21386
  56. Parry-Jones A
    Albert M
    The 2017 ISBER Annual Meeting & Exhibits in Toronto “Due North: Aligning Biobanking Practice with Evolving Evidence and Innovation
    Biopreservation and Biobanking 2016 Dec;14(6):563-564. Epub 2016 Nov 21 https://doi.org/10.1089/bio.2016.29013.apj
  57. Au KK
    Le Page C, Ren R, Meunier L, et al
    STAT1-associated intratumoural TH1 immunity predicts chemotherapy resistance in high-grade serous ovarian cancer
    J Path: Clin Res October 2016; 2: 259–270 DOI: 10.1002/cjp2.55
  58. Le Page C
    Kobel M, Rahimi K, Bernardini M, Meunier L, Porlelance L, de Ladurantaye M
    COEUR: A pan Canadian platform for the development of biomarker-driven subtype specific management of ovarian cancer
    Poster 2016
  59. Al-Hashimi A
    Shayegan B
    Austin R
    Effect of anti-GRP78 autoantibodies on prostate cancer progression through tissue factor procoagulant activity
    Journal of Clinical Oncology 34, no. 2_suppl (January 2016) 258-258. DOI: 10.1200/jco.2016.34.2_suppl.258
  60. Le Page C
    Kobel M
    Rahimi K
    Bernardini M
    Meunier L
    Porlelance L
    de Ladurantaye M
    COEUR: A pan Canadian platform for the development of biomarker-driven subtype specific management of ovarian cancer
    Poster
  61. Henderson M
    Simeon-Dubach D
    Albert M
    Finding the Path to Biobank Sustainability Through Sound Business Planning
    Biopreservation and Biobanking 2015 Dec;13(6):385-6 https://doi.org/10.1089/bio.2015.29039.mh
  62. Barnes RO
    Schacter B
    Kodeeswaran S
    CTRNet Management Committee
    Watson PH
    Funding Sources for Canadian Biorepositories: The Role of User Fees and Strategies to Help Fill the Gap
    Biopreservation and Biobanking. October 2014, 12(5): 300-305. https://doi.org/10.1089/bio.2014.0052
  63. Nesset KA
    Perri AM
    Mueller CR
    Frequent Promoter Hypermethylation and Expression Reduction of the Glucocorticoid Receptor Gene in Breast Tumours
    Epigenetics, 9:6, 851-859, DOI: 10.4161/epi.28484
  64. Watson PH
    Nussbeck SY
    Carter C
    O'Donoghue S
    et al
    A Framework for Biobank Sustainability
    Biopreservation and Biobanking. February 2014, 12(1): 60-68; https://doi.org/10.1089/bio.2013.0064
  65. Matzke E A.M
    O'Donoghue S
    O. Barnes R
    Daudt H
    et al
    Certification for Biobanks: The Program Developed by the Canadian Tumour Repository Network (CTRNet)
    Biopreserv Biobank. 2012 Oct;10(5):426-32. doi: 10.1089/bio.2012.0026.
  66. Kelly NJ
    Varga JFA
    Specker EJ
    Romeo CM
    Coomber BL
    Uniacke J
    Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion
    Oncogene. 2017; doi:10.1038/onc.2017.372
  67. Lachance G
    Uniacke J
    Audas TE
    Holterman CE
    Franovic A
    Payette J
    Lee S
    DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia
    Proc Natl Acad Sci USA. 2014; 111(21): 7783–7788.
  68. Köbel M
    Rahimi K
    Rambau PF
    Naugler, C
    et al
    An Immunohistochemical Algorithm for Ovarian Carcinoma Typing
    International Journal of Gynecological Pathology. 2016; 35:430–441. DOI: 10.1097/PGP.0000000000000274
  69. The Cancer Genome Atlas Research Network
    Integrated genomic characterization of oesophageal carcinoma
    Nature. 2017; doi:10.1038/nature20805.
  70. Loiselle JJ
    Roy JG
    Sutherland LC
    RBM5 reduces small cell lung cancer growth, increases cisplatin sensitivity and regulates key transformation-associated pathways
    Heliyon 2016 2(11): e00204, DOI: 10.1016/j.heliyon.2016.e00204
  71. Majumder M
    Xin X
    Liu L
    Tutunea-Fatan E
    Rodriguez-Torres M
    Vincent K
    Postovit LM
    Hess D
    Lala PK
    COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis.
    Stem Cells. 2016; 14. doi: 10.1002/stem.2426.
  72. Ho N
    Coomber B
    Hexokinase II expression is correlated with colorectal cancer prognosis.
    Cancer Treatment and Research Communications. 2016; 6: 11-16. DOI: https://doi.org/10.1016/j.ctrc.2016.02.008
  73. The Cancer Genome Atlas Research Network
    Linehan WM
    Spellman PT
    Ricketts CJ
    et al
    Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
    N Engl J Med. 2016; 14:135-45. doi: 10.1056/NEJMoa1505917.
  74. Hirte H
    Hotte SJ
    Kavsak PA
    Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer.
    Applied Mathematics, Medicine, Cell Biology, 2016; 2(1): DOI: 10.1016/j.heliyon.2015.e00059.
  75. Majumder M
    Landman E
    Liu L
    Hess D
    et al
    COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation.
    Mol Cancer Res. 2015; 13:1022-33. doi: 10.1158/1541-7786.MCR-14-0543.
  76. Koti M
    Siu A
    Clément I
    et al
    A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer.
    Br J Cancer. 2015; 113:1746. doi:10.1038/bjc.2015.459.
  77. Albert M
    Bartlett J
    Johnston RN
    et al
    Biobank bootstrapping: is biobank sustainability possible through cost recovery?
  78. Fahmy N
    Woo M
    Alameldin M
    et al
    Investigating Ochratoxin A and Biotin Levels in Patients with Renal Carcinoma.
    Northeastern Section of the American Urological Association 64th Annual Meeting, Niagara Falls, Canada. September 2012. Moderated Poster
  79. Fahmy N,
    Woo M
    Alameldin M
    et al
    Endogenous biotin expression in renal and testicular tumours and literature review.
    Canadian Urological Association Journal. 2014; 8: 268- 272.doi:10.5489/cuaj.1810.
  80. Matzke
    Dee S
    Bartlett J
    et al
    A practical tool for modeling biospecimen user fees.
    Biopreserv Biobank. 2014;12: 234-9. doi: 10.1089/bio.2014.0008.
  81. The Cancer Genome Atlas Research Network.
    Comprehensive molecular characterization of gastric adenocarcinoma.
    Nature. 2014; 11: 202-9. doi: 10.1038/nature13480.
  82. The Cancer Genome Atlas Research Network
    Comprehensive molecular profiling of lung adenocarcinoma.
    Nature. 2014; 511:543-50. doi: 10.1038/nature13385.
  83. The Cancer Genome Atlas Research Network.
    Comprehensive molecular characterization of urothelial bladder carcinoma.
    Nature. 2014; 507: 315-22. doi: 10.1038/nature12965.
  84. Letellier E
    Schmitz M
    Baig K
    et al
    Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.
    British Journal of Cancer. 2014; 111: 726-735.
  85. Fahmy N
    Woo M
    Alameldin M
    et al
    Ochratoxin A is not detectable in renal and testicular tumours.
    Canadian Urological Association Journal. 2014; 8: 40-6.
  86. Peltekova V
    Lemire M
    Qazi A
    et al
    Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.
    Int. J. Cancer: 2014; 134: 2330–2341.
  87. Whiteside E
    Seim I
    O'Keeffe A
    et al
    Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines.
    International Journal of Oncology, 2013; 43: Issue 2.
  88. Griffith M
    Mwenifumbo J
    Cheung P
    et al
    Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.
    The Pharmacogenomics Journal. 2013; 13: 148–158.
  89. Fontebasso A
    Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas.
    Acta Neuropathol. 2013; 125:659–669.
  90. Nicholas J
    Andersen BJ
    Nickoloff KJ
    et al
    Pharmacologic inhibition of MEK signaling prevents growth of canine hemangiosarcoma.
    Molecular Cancer Theraputics, 2013; 12: 1701-1714.
  91. Dulak A
    Stojanov P
    Peng S
    et al
    Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.
    Nature Genetics 2013; 45: 478-486.
  92. Novak A
    Binnington B
    Ngan B
    et al
    Cholesterol masks membrane glycosphingolipid tumor-associated antigens to reduce their immunodectection in human cancer biopsies.
    Glycobiology. 2013; 23.1230-9.
  93. Koti M
    Gooding R
    Nuin P
    et al
    Identification of the IGF1/PI3K/NF κB/ERK gene signaling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer.
    BMC Cancer. 2013; 13: 549.
  94. Farquharson M
    Al-Ebraheem A
    Cornacchi G
    et al
    The use of X-ray interaction data to differentiate malignant from normal breast tissue at surgical margins and biopsy analysis.
    X-Ray Spectrom. 2013; 42, 349–358.
  95. The Cancer Genome Atlas Research Network.
    Integrated genomic characterization of endometrial carcinoma.
    Nature. 2013: 497, 67-73. doi: 10.1038/nature12113.
  96. Barnes R
    Albert M
    Damaraju S
    et al
    Generating a comprehensive set of standard operating procedures for a biorepository network-The CTRNet experience.
    Biopreserv Biobank. 2013; 11:387-96. doi: 10.1089/bio.2013.0061.
  97. Hembrough T
    Thyparambil S
    Liao W
    Application of Selected Reaction Monitoring for Multiplex Quantification of Clinically Validated Biomarkers in Formalin-Fixed, Paraffin-Embedded Tumour Tissue.
    The Journal of Molecular Diagnostics. 2013; 15: 454-465.
  98. Thériault BL
    Pajovic S
    Bernardini MQ
    Shaw PA
    Gallie BL
    Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer.
    Int. J. Cancer. 2012; 130: 1844–1854. doi:10.1002/ijc.26189.
  99. Haslehurst AM
    Koti M
    Dharsee M
    et al
    EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer.
    BMC Cancer. 2012;12:91. doi:10.1186/1471-2407-12-91.
  100. Schwartzentruber J
    Korshunov A
    Liu XY
    Jones DT
    Pfaff E
    Jacob K
    Sturm D
    Fontebasso AM
    Quang DA
    Tönjes M
    et al
    Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
    Nature. 2012;482:226–231.
  101. Pinto DM
    Chisholm K
    O’Connor-McCourt M
    Wang E
    Leslie A
    Kostyleva R
    Cohen A
    Intra-protein variability revealed by absolute quantification of plasma proteins using dimethyl labelling.
    Paper presented at: 4th Annual Symposium of the Canadian National Proteomics Network; 2012 Apr 23-25; Toronto, ON.
  102. Fahmy N
    Woo M
    MacDonald K
    Goneau L
    Cadieux P
    Pautler S
    Investigating Ochratoxin A and Biotin Levels in Patients with Renal Carincoma.
    Paper presented at: 64th Annual Meeting of the Northeastern Section of the American Urological Association; 2012 Sep 13-15; Niagara Falls.
  103. The Cancer Genome Atlas Research Network
    Comprehensive genomic characterization of squamous cell lung cancers.
    Nature.2012; 489(7417), 519–525. http://doi.org/10.1038/nature11404
  104. Quail DF
    Walsh LA
    Zhang G
    et al
    Embryonic protein nodal promotes breast cancer vascularization.
    Cancer Research. 72; 3851–63.
  105. Laguë M-N
    Romieu-Mourez R
    Bonneil É
    Boyer A
    Pouletty N
    Mes-Masson A-M
    et al
    Proteomic Profiling of a Mouse Model for Ovarian Granulosa Cell Tumor Identifies VCP as a Highly Sensitive Serum Tumor Marker in Several Human Cancers.
    PLoS ONE. 2012; 7(8): e42470. doi:10.1371/journal.pone.0042470.
  106. Rico C
    Lague MN
    Lefevre P
    Tsoi M
    Dodelet-Devillers A
    Kumar V
    et al
    Pharmacological targeting of mammalian target of rapamycin inhibits ovarian granulosa cell tumor growth.
    Carcinogenesis. 2012;33(11):2283–92. doi: 10.1093/carcin/bgs263.
  107. Chikova A
    Bernard HU
    Shchepotin IB
    Grando SA
    New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer.
    Life Sciences. 2012; 91(21-22), 1103–1108. http://doi.org/10.1016/j.lfs.2011.12.023.
  108. Mersov A
    Mersov G
    Al-Ebraheem A
    Cornacchi S
    Gohla G
    Lovrics P
    Farquharson MJ
    The differentiation of malignant and benign human breast tissue at surgical margins and biopsy using x-ray interaction data and Bayesian classification.
    Radiation of Physics and Chemistry.2012; 95: 210-2013. http://dx.doi.org/10.1016/j.radphyschem.2012.12.014.
  109. Girgis AH
    Iakovlev VV
    Beheshti B
    et al
    Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma.
    Cancer Research. 2012;72(20):5273–5284. doi: 10.1158/0008-5472.CAN-12-0656.
  110. Li Q
    Tainsky MA
    Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses.
    PLoS ONE. 2011; 6(12), e28683. http://doi.org/10.1371/journal.pone.0028683.
  111. Ward A
    Morettin A
    Shum D
    Hudson JW
    Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice.
    BMC cancer. 2011; 71. doi:101186/1471-2407-11-71.
  112. Huang Y
    Sohn KY
    Phan K
    Dhesy-Thind S
    Hill S
    Hirte H
    Hotte S
    Worster A
    Kavsak P
    NT-proBNP measurement using a multiplex platform in cancer and chest pain populations.
    Clinical Biochemistry. 2011; 44: 1172.
  113. Cin H
    Meyer C
    Herr R
    et al
    Oncogenic FAM131B–BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma.
    Acta Neuropathol. 2011; 121: 763. doi:10.1007/s00401-011-0817-z.
  114. Hill J
    Tremblay TL
    Pent A
    Li J
    Robotham A
    Lenferink AE
    Wang E
    O’Connor-McCourt M
    Kelly JF
    Identification of vascular breast tumour markers by laser capture microdissection and label-free LC-MS.
    J Proteome Res. 2011; 10(5): 2479-2493.
  115. Lambrot R
    Kimmins S
    Histone methylation is a critical regulator of the abnormal expression of POU5F1 and RASSF1A in testis cancer cell lines.
    International Journal of Andrology. 2011; 34: 110–123. doi:10.1111/j.1365-2605.2010.01063.x
  116. White NMA
    et al
    miRNA Profiling in Metastatic Renal Cell Carcinoma Reveals a Tumour-Suppressor Effect for miR-215.
    British Journal of Cancer. 2011; 105(11): 1741–1749.
  117. Huang Y
    Dhesy-Thind S
    Hirte H
    Hotte S
    Kavsak P
    Establishing a reference interval for the high sensitive Troponin T assay in treatment-naïve cancer patients.
    Accepted abstract in: AACC; 2011.
  118. Jha KN
    Wong L
    Zerfas PM
    et al
    Identification of a Novel HSP70-binding Cochaperone Critical to HSP90-mediated Activation of Small Serine/Threonine Kinase.
    The Journal of Biological Chemistry. 2010; 285(45):35180-35187. doi:10.1074/jbc.M110.134767.
  119. Weerawardane S
    Analyzing The Biological Role Of The Transcription Factor Kaiso In Breast Tumourigenesis.
    Graduate Studies. McMaster University, 2010. Print.
  120. Misquitta-Ali CM
    Cheng E
    O’Hanlon D
    et al
    Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer.
    Molecular and Cellular Biology. 2011; 31(1):138-150. doi:10.1128/MCB.00709-10.
  121. Henley SA
    Francis SM
    Demone J
    Ainsworth P
    Dick FA
    A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions.
    Cancer Cell International. 2010; 10:8. doi:10.1186/1475-2867-10-8.
  122. Al-Halabi H
    Nantel A
    Klekner A
    et al
    Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma.
    Acta Neuropathol. 2010; 121: 229. doi:10.1007/s00401-010-0780-0.
  123. Donaldson NS
    Nordgaard CL
    Pierre CC
    Kelly KF
    Robinson SC
    et al
    Kaiso regulates Znf131-mediated transcriptional activation.
    Exp Cell Res. 2010; 316: 1692–1705.
  124. Lu X
    Zhang K
    Van Sant C
    et al
    An algorithm for classifying tumors based on genomic aberrations and selecting representative tumor models.
    BMC Med Genomics. 2010; 3: 23.
  125. Henderson MPA
    Hirte H
    Hotte SJ
    Kavsak PA
    Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer.
    Heliyon. 2010; 2(1):e00059. doi:10.1016/j.heliyon.2015.e00059.
  126. Englert D
    Wilson D
    Laken S
    Amplification of mRNA from Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues without 3' Bias and Multiplex Expression Analysis on Flow-Through Microarrays.
    Cancer Res. 2009; 69: 3052; DOI: 10.1158/0008-5472.SABCS-09-3052.
  127. Kavsak PA
    Lee A
    Hirte H
    Young E
    Gauldie J
    Cytokine elevations in acute coronary syndrome and ovarian cancer: a mechanism for the up-regulation of the acute phase proteins in these different disease etiologies.
    Clin Biochem. 2008; 41:607–610.
  128. Kavsak PA
    Lee A
    Hirte H
    Young E
    Gauldie J
    Pilot study assessing the utility of an adhesion array and high-sensitivity cytokine array as surrogate biomarkers in ovarian cancer.
    Clin Biochem. 2008; 41:1271.