Ontario Tumour Bank – Advancing Cancer Research for Over 20 Years
For more than two decades, the Ontario Tumour Bank (OTB) has been a cornerstone in support of both academic and industry research. Our reach extends throughout Ontario, across Canada, and US, and internationally.
OTB’s Research Impact
To date, OTB has supported more than 200 publications, amassing over 70,000 citations. This includes more than 70 publications in high impact journals such as Nature and Cell Press that have significantly advanced discovery cancer research that is improving patient care.
Selected publications supported by OTB:
- Geographic variation of mutagenic exposures in kidney cancer genomes. S Senkin, S Moody, M Díaz-Gay, B Abedi-Ardekani, T Cattiaux, et al. Nature 2024, 1-9.
- Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions. MP Purdue, D Dutta, MJ Machiela, BR Gorman, T Winter, D Okuhara, et al. Nature Genetics 2024, 1-10.
- The Mutographs biorepository: A unique genomic resource to study cancer around the world. S Perdomo, B Abedi-Ardekani, AC de Carvalho, A Ferreiro-Iglesias, et al. Cell Genomics 2024, 4(3):100500.
- ABCC2 brush‐border expression predicts outcome in papillary renal cell carcinoma: a multi‐institutional study of 254 cases. VF Castillo, M Masoomian, K Trpkov, M Downes, F Brimo, et al. Histopathology 2023, 83 (6), 949-958.
- Minimally invasive detection of cancer using metabolic changes in tumor-associated natural killer cells with Oncoimmune probes. D Ishwar, R Haldavnekar, K Venkatakrishnan, B Tan. Nature Communications 2022, 13 (1), 4527.
- The entry of nanoparticles into solid tumours. S Sindhwani, AM Syed, J Ngai, BR Kingston, L Maiorino, J Rothschild, et al. Nature Materials 2020, 19 (5), 566-575.
- The repertoire of mutational signatures in human cancer. LB Alexandrov, J Kim, NJ Haradhvala, MN Huang, AW Tian Ng, Y Wu, et al. Nature 2020, 578 (7793), 94-101.
- Comprehensive molecular characterization of mitochondrial genomes in human cancers. Y Yuan, YS Ju, Y Kim, J Li, Y Wang, CJ Yoon, Y Yang, I Martincorena, et al. Nature Genetics 2020, 52 (3), 342-352.
- Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. B Rodriguez-Martin, EG Alvarez, A Baez-Ortega, J Zamora, F Supek, et al. Nature Genetics 2020, 52 (3), 306-319.
- The immune landscape of cancer. V Thorsson, DL Gibbs, SD Brown, D Wolf, DS Bortone, THO Yang, et al. Immunity 2018, 48 (4), 812-830. e14.
A complete list of research publications supported by OTB are available here.
We’d like to see your publications using OTB samples and data! Please email us at tumourbank@oicr.on.ca.
OTB’s network of users and research collaborators includes:
Ontario
- Lincoln Stein, Ontario Institute for Cancer Research, Toronto, ON
- Jane Bayani, Ontario Institute for Cancer Research, Toronto, ON
- Scott Bratman, University Health Network, Toronto, ON and Adela Bio, Toronto, ON and San Francisco, CA
- Warren Chan, University of Toronto, Toronto, ON (Canada Research Chair in Nanobioengineering)
- Bo Tan, Toronto Metropolitan University, Toronto, ON
- Krishnan Venkatakrishnan, Toronto Metropolitan University, Toronto, ON
- Rola Saleeb, Unity Health Toronto, Toronto, ON
- Hon Leong, Sunnybrook Health Sciences Centre, Toronto, ON
- James Uniacke, University of Guelph, Guelph, ON
- Christopher Mueller, Queen’s University, Kingston, ON
- Christina Addison, University of Ottawa, Ottawa, ON
- Richard Austin, McMaster University, Hamilton, ON
- Michael Farquharson, McMaster University, Hamilton, ON
- Dale Laird, University of Western Ontario, London, ON
Across Canada
- Anne‐Marie Mes‐Masson, University of Montreal, Montreal, QC
- Peter Siegel, McGill University, Montreal, QC
- William Foulkes, McGill University, Montreal, QC
- Sherif Abou-Elela, University of Sherbrooke, Sherbrooke, QC (Canada Research Chair in RNA Biology and Cancer Genomics)
- Jiuyong Xie, University of Manitoba, Winnipeg, MB
- Peter Watson, University of British Columbia, Vancouver, BC
- Karla Williams, University of British Columbia, Vancouver, BC (Canada Research Chair in Oncology)
- Ryan Morin, Simon Fraser University, Vancouver, BC
USA
- Mark Purdue, National Cancer Institute, Rockville, MD, USA
- Ludmil Alexandrov, University of California, San Diego, CA, USA
International